Analysis of cell proliferation index using the Ki-67 Antigen in odontogenic keratocyst: a systematic review

Abstract

Objective: this review aims to analyze scientific articles about cell proliferation index using Ki-67 in odontogenic keratocyst and compare these papers to estimate the average index of this lesion. Material and Methods: two researchers performed a literature search independently in the MEDLINE/PubMed database and 28 articles containing relevant data were selected. Results: the immunohistochemical analysis methodology showed great variability among all the papers, with unclear and unified methodologies, making the comparison among different studies difficult. Conclusion: considering odontogenic keratocyst as a lesion with an uncommon clinical behavior, an adequate classification for it is necessary, so an appropriate treatment with a good prognosis for the patient can be established according to its nature. A standardization is needed so immunohistochemical analyses will find reliable data to classify properly this lesion.