Evaluation of laminin-332 in tumorigenesis of oral squamous cell carcinoma: a literature review.

Abstract

Objective: to verify if laminin-332 is a marker of alterations in early processes of carcinogenesis. Material and Methods: this is a review of the literature, based on the selection and analysis of original articles and review, published between 1997 and 2015 in the electronic portal PubMed, Academic Google and periodical portal of the Coordination of Improvement of Personnel of Higher Education (CAPES). Results: 36 articles were selected using the descriptors: “oral”; “Squamous cell carcinoma”; “Laminin-332 or laminin-5,” “oral dysplastic cells,” “potentially malignant disorders” that correlated the progression, progression and / or invasion of the tumor progression process with laminin-332 or the expression of that glycoprotein in dysplasias and carcinoma oral. Conclusion: the variation of the presentation of laminin-332 was directly related to the evolution of cancer. Thus, understanding the role of this molecule in tumor biology may help in understanding the progression of the disease.